Selection Sunday is barely in the rearview mirror, and the numbers are already shouting at us from every sportsbook screen in America. Duke, Arizona, Michigan, and defending champion Florida open as the tournament’s top dogs, and the first-round odds say they should stroll through their openers. DraftKings and ESPN’s Basketball Power Index (BPI) agree on one thing: the heavyweights are, well, heavy favorites.
Michigan sits as the frontrunner to win a national championship, marking the program's first since 1989 under Steve Fisher. The Wolverines have a 25-1 record this season, with their only loss coming against Wisconsin. Michigan's five starters all average double figures in scoring, and they are the best defensively in the Big Ten.

The First Four in Dayton is usually where the nerves show first, and this year is no different. UMBC, forever branded by that historic upset of Virginia, is actually the favorite this time, laying 1.5 against Howard with BPI giving the Retrievers a 55.9% edge.
Duke's national championship odds will be enhanced with a win over Michigan, and they aim to maintain their standing as the 1-seed in the East. Freshman Cameron Boozer is a standout player, contributing significantly to Duke's performance.

Houston's success this season revolves around strong guard play, with Kingston Flemings and Emanuel Sharp providing 16.5 points per game each. The Cougars are trying to avoid late-season stumbles in Big 12 play.
Arizona started the season with 23 consecutive victories before recent losses to Kansas and Texas Tech. The Wildcats have impressive nonconference wins and hold the same national title odds as Duke and Houston.

Florida, the defending champion, is hitting its stride with a seven-game winning streak in the SEC. They would need to come out of the Midwest as a No. 3 seed to reach the Final Four.
Once we move to Thursday, the divide between the bluebloods and the hopefuls is obvious. Duke is a towering 29.5-point favorite over Siena, with BPI saying the Blue Devils win 99% of the time.
For all the talk about parity, the opening board still tilts toward the usual brands. That said, Thursday isn’t just a coronation schedule for the elites.
The upcoming Saturday schedule is set to be the busiest of the college basketball season, featuring a massive Big 12 showdown between No. 2 Houston and No. 4 Arizona, and a rare nonconference treat between No. 1 Michigan and No. 3 Duke. These high-stakes matchups will further shape conference races and illuminate the form of the sport's top title contenders.
